2-Bromo-1-[1-[(4-methoxyphenyl)methyl]-1H-pyrazol-4-yl]-1-propanone → HCID 86658548, compound

Participants

Reaction Steps

According to Scheme 2 Step 4: A solution of 2-bromo-1-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)propan-1-one (0.36 mmol, 116 mg) and of 1-(6-iodopyridin-2-yl)thiourea (0.36 mmol, 100 mg) in acetone (1.8 mL) was stirred at 60° C. for 2 days. The precipitate formed was filtered and was washed with Et2O to yield N-(4-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-5-methylthiazol-2-yl)-6-iodopyridin-2-amine hydrobromide (0.23 mmol, 136 mg, 65%) as a white solid.

Provenance & Evidence