Sodium Carbonate → HCID 46837061, compound

Participants

Reaction Steps

According to Scheme 9 Step 4: A solution of 4-(1-(4-methoxybenzyl)-1H-pyrazol-4-yl)-N-(4-methylpyrimidin-2-yl)-5-(trifluoromethyl)thiazol-2-amine (0.40 mmol, 180 mg) and trifluoromethanesulfonic acid (4.84 mmol, 430 μL) in TFA (1 mL) was stirred for 8 minutes at 80° C. under microwave activation. The reaction solution was neutralized with a saturated aqueous solution of Na2CO3 and extracted with AcOEt. The combined organic layers were dried over MgSO4, were filtered and were evaporated under reduced pressure to give a brown solid. The resulting crude product was purified by flash chromatography over silica gel using DCM/MeOH (100:0 to 95:5) to yield N-(4-methylpyrimidin-2-yl)-4-(1H-pyrazol-4-yl)-5-(trifluoromethyl)thiazol-2-amine (22 μmol, 7 mg, 5.5%) as a white solid.

Provenance & Evidence