Water → HCID 178428575, compound

Participants

Reaction Steps

According to Scheme 12 Step 2: A solution of 4-(1-(4-methoxybenzyl)-3-phenyl-1H-pyrazol-4-yl)-N-(4-methylpyrimidin-2-yl)thiazol-2-amine (0.17 mmol, 77 mg) in TFA (1 mL) was stirred at 150° C. for 5 minutes under microwave heating. Water was added and was extracted with DCM. The organic layer was dried over MgSO4, was filtered and was concentrated. The crude compound was purified by flash chromatography with silica gel using DCM/AcOEt (100:10 to 50:50) to yield N-(4-methylpyrimidin-2-yl)-4-(3-phenyl-1H-pyrazol-4-yl)thiazol-2-amine (90 μmol, 30 mg, 50%) as a yellow solid.

Provenance & Evidence