Potassium Cyanide → HCID 86658569, compound

Participants

Reaction Steps

According to Scheme 13 Step 1: A solution of N-(4-(1-(4-methoxybenzyl)-3-chloro-1H-pyrazol-4-yl)thiazol-2-yl)pyridin-2-amine (75 μmol, 30 mg), KCN (75 μmol, 4.9 mg), Pd(PPh3)4 (7.5 μmol, 8.7 mg) and CuI (75 μmol, 14.4 mg) in acetonitrile (2 mL) was microwaved at 180° C. for 50 minutes under nitrogen. After evaporation of the solvent, the crude residue was dissolved in AcOEt. The organic phase was washed with a saturated aqueous solution of Na2CO3, was dried over MgSO4, was filtered and was concentrated to yield 1-(4-methoxybenzyl)-4-(2-(pyridin-2-ylamino)thiazol-4-yl)-1H-pyrazole-3-carbonitrile (51 μmol, 20 mg, 68%).

Provenance & Evidence