反应详情

温度

50 °C

To a solution of 1-(4-bromo-2-methylphenyl)-4,4,4-trifluorobutan-1-ol (545 g) in toluene (5.4 L) was added thionyl chloride (393 g) at room temperature. The reaction mixture was stirred at 50° C. overnight and concentrated under reduced pressure to give the title compound. This reaction was performed for 3 batches, and the obtained compounds were used in step D without further purification.

1. concentrationconcentrated under reduced pressure