(4-Methoxyphenyl)boronic acid → HCID 131733102, compound

Participants

Reaction Steps

A reaction mixture of ethyl (3R)-1-(4-((1-(4-bromo-2-methylphenyl)-4,4,4-trifluorobutyl)amino)benzoyl)piperidine-3-carboxylate (200 mg), palladium acetate (4.0 mg), potassium fluoride (62.8 mg), 4-methoxyphenylboronic acid (109 mg), 2-(di-tert-butylphosphino)biphenyl (10.7 mg) and tetrahydrofuran (2 mL) was stirred at room temperature overnight under a nitrogen atmosphere. The reaction mixture was added to water, and the mixture was extracted with ethyl acetate. The extract was washed with water and saturated brine, dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate) to give the title compound (0.173 g).

Provenance & Evidence