Hydrochloric Acid → (3R)-1-(4-((4,4,4-trifluoro-1-(2-methyl-4-(4,5,6,7-tetrahydro-2H-indazol-2-yl)phenyl)butyl)amino)benzoyl)piperidine-3-carboxylic acid

Participants

Reaction Steps

To a mixture of ethyl (3R)-1-(4-((4,4,4-trifluoro-1-(2-methyl-4-(4,5,6,7-tetrahydro-2H-indazol-2-yl)phenyl)butyl)amino)benzoyl)piperidine-3-carboxylate (155.4 mg), THF (0.5 mL) and ethanol (0.5 mL) was added 1M aqueous sodium hydroxide solution (0.521 mL), and the mixture was stirred at room temperature for 1 hr. To the reaction mixture was added 1M hydrochloric acid (0.6 and the mixture was extracted with ethyl acetate. The extract was washed with water and saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to give the title compound (131.6 mg).

Provenance & Evidence