HCID 117839903, compound → HCID 117840145, compound

HRID 1520295Notes

Reaction equation

HRID 1520295 reaction equation
Cl[C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[CH:10][C:11]([C:14](=[N:21]OC)[CH2:15][CH2:16][C:17]([F:20])([F:19])[F:18])=[N:12][CH:13]=2)=[CH:4][CH:3]=1>[Pd].CO>[F:20][C:17]([F:18])([F:19])[CH2:16][CH2:15][CH:14]([C:11]1[CH:10]=[CH:9][C:8]([C:5]2[CH:6]=[CH:7][CH:2]=[CH:3][CH:4]=2)=[CH:13][N:12]=1)[NH2:21]

Participants

4

Reactant 1

HCID 117839903HCID 117839903, compound

Product 1

HCID 117840145HCID 117840145, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

Under a hydrogen atmosphere, a mixture of 1-(5-(4-chlorophenyl)pyridin-2-yl)-4,4,4-trifluoro-N-methoxybutan-1-imine (169.5 mg), palladium on carbon (263 mg) and methanol (1.648 mL) was stirred at room temperature overnight. The insoluble material was filtered off through celite, the filtrate was washed with 1M aqueous sodium hydroxide solution and saturated brine, and the solvent was evaporated under reduced pressure to give the title compound as a crudely purified product. This compound was used in step F without further purification.

Workup

  1. filtrationThe insoluble material was filtered off through celite
  2. washthe filtrate was washed with 1M aqueous sodium hydroxide solution and saturated brine
  3. customthe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-ae25dbd73b704cfaa0815736d0025d66
Source dataset
uspto-grants-2015_07
Patent number
US09073864B2

Reaction notes

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