反应详情

Under a hydrogen atmosphere, a mixture of 1-(5-(4-chlorophenyl)pyridin-2-yl)-4,4,4-trifluoro-N-methoxybutan-1-imine (169.5 mg), palladium on carbon (263 mg) and methanol (1.648 mL) was stirred at room temperature overnight. The insoluble material was filtered off through celite, the filtrate was washed with 1M aqueous sodium hydroxide solution and saturated brine, and the solvent was evaporated under reduced pressure to give the title compound as a crudely purified product. This compound was used in step F without further purification.

1. filtrationThe insoluble material was filtered off through celite
2. washthe filtrate was washed with 1M aqueous sodium hydroxide solution and saturated brine
3. customthe solvent was evaporated under reduced pressure