1-Hydroxybenzotriazole → HCID 131733106, compound

Participants

Reaction Steps

A mixture of 4-((2-methyl-1-(2-methyl-4-(4,5,6,7-tetrahydro-2H-indazol-2-yl)phenyl)propyl)amino)benzoic acid obtained in step C, ethyl (3R)-piperidine-3-carboxylate (0.106 mL), 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (132 mg), 1-hydroxybenzotriazole (93 mg), N,N-diisopropylethylamine (0.180 mL), 4-dimethylaminopyridine (4.2 mg) and DMF (0.860 mL) was stirred at room temperature overnight. To the reaction mixture was added water, and the mixture was extracted with ethyl acetate. The extract was washed with water and saturated brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure and the residue was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (152.3 mg).

Provenance & Evidence