HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1520396Generated: November 2, 2026
5-Chloromethyloxazolidin-2-one → HCID 67298101, compound
https://huagongshe.com/reaction/1520396
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 5-Chloromethyloxazolidin-2-one | HCID 90815 | — |
| Reactant | 2-((1,1-Dimethylethyl)imino)-N,N-diethylhexahydro-1,3-dimethyl-2lambda5-1,3,2-diazaphosphorin-2-amine | HCID 3513851 | — |
| Reactant | HCID 67297993 | HCID 67297993 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | HCID 67298101 | HCID 67298101 | — |
Reaction Steps
To 5-(chloromethyl)oxazolidin-2-one (45 μmol) was added the solution of 3-(4-(methylamino)-2-(pyridin-3-yl)quinazolin-6-yl)phenol (30 μmol) in NMP (200 μL). PS-BEMP (90 μmol) was added to the vials by resin dispenser. After the reaction mixture was heated at 90° C. for 12 h, the residue was diluted with methanol and purified by PREP-HPLC Condition D. The target fraction was lyophilized to afford the titled compound whose structure was finally confirmed by LCMS using LCMS Method E.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09073890B2 |
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| Source dataset | uspto-grants-2015_07 |
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| ORD ID | ord-94e609f8406b48db9ca1eaa19705cdd6 |
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| Source note | uspto-grants-2015_07 |
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