HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-(Hydroxymethyl)pyridine-3-boronic acid → 2,2-dichloro-1-((4S,5R)-4-(fluoromethyl)-5-(4-(6-(hydroxymethyl)pyridin-3-yl)phenyl)-2,2-dimethyloxazolidin-3-yl)ethanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-(Hydroxymethyl)pyridine-3-boronic acid | HCID 44118255 | — |
| Reactant | (4S,5R)-3-(dichloroacetyl)-4-(fluoromethyl)-5-(4-iodophenyl)-2,2-dimethyl-1,3-oxazolidine | HCID 86695394 | — |
| Product | 2,2-dichloro-1-((4S,5R)-4-(fluoromethyl)-5-(4-(6-(hydroxymethyl)pyridin-3-yl)phenyl)-2,2-dimethyloxazolidin-3-yl)ethanone | HCID 86695406 | — |
Reaction Steps
Following the general procedure of Example 1—Step 1 and making non-critical variations but using 2,2-dichloro-1-((4S,5R)-4-(fluoromethyl)-5-(4-iodophenyl)-2,2-dimethyloxazolidin-3-yl)ethanone and (6-(hydroxymethyl)pyridin-3-yl)boronic acid as starting materials the title compound is obtained (800 mg): m/z (Cl) M−H 426.1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09073894B2 |
| Source dataset | uspto-grants-2015_07 |
| ORD ID | ord-ccfa438a75084f05ae10a2cc9e9278e9 |
| Source note | uspto-grants-2015_07 |