HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetone → (4S,5R)-4-(fluoromethyl)-5-(4-iodophenyl)-2,2-dimethyloxazolidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetone | HCID 180 | — |
| Reactant | (2S,1R)-2-Amino-3-fluoro-1-(4-iodo-phenyl)-propan-1-ol | HCID 45257860 | — |
| Product | (4S,5R)-4-(fluoromethyl)-5-(4-iodophenyl)-2,2-dimethyloxazolidine | HCID 86695412 | — |
Reaction Steps
Acetone (150 mL) is added to commercially available (1R,2S)-2-amino-3-fluoro-1-(4-iodophenyl)propan-1-ol (15.0 g, 50.8 mmol). After stirring overnight at room temperature the solvent is removed under reduced pressure to give the title compound (17.6 g): m/z (C1) M+H 335.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09073894B2 |
| Source dataset | uspto-grants-2015_07 |
| ORD ID | ord-a027bf836e264cb68fdafdd0d365a52d |
| Source note | uspto-grants-2015_07 |