Hydrochloric Acid → 3-(5-Bromopyridin-2-yl)oxetan-3-aminium chloride

Participants

Reaction Conditions

Reaction Steps

To a methanol (15 ml) solution of N-(3-(5-bromopyridin-2-yl)oxetan-3-yl)-2-methylpropane-2-sulfinamide (850 mg, 2.55 mmol) that had been cooled to 0° C. is added 4N HCl in dioxane (1.3 ml, 5.2 mmol). The solution is stirred for 1 hour at 0° C. The volatiles were removed by rotary evaporation at low pressure. After several evaporation cycles using acetonitrile (3×10 ml) the title product is obtained (584 mg): m/z (Cl) 229, 231 [M+H]+.

Provenance & Evidence