Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | Bis(benzyloxy)(diisopropylamino)phosphine | HCID 196621 | — |
| Reactant | Hydrogen peroxide water | HCID 449047 | — |
| Reactant | Sodium Bisulfate | HCID 516919 | — |
| Reactant | benzyl (1-(5-(4-((1R,2S)-2-(2,2-difluoroacetamido)-3-fluoro-1-hydroxypropyl)phenyl)pyridin-2-yl)ethyl)carbamate | HCID 86695504 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 86695505 | HCID 86695505 | — |
Reaction Steps
Trifluoroacetic acid (51.6 μL) is added to the product of step 3, Example 95A (0.168 g, 0.335 mmol) and pyridine (54.2 μL, 0.67 mmol) in THF (4.4 mL, 54 mmol) at 0° C. After 5 minutes, bis(benzyloxy)(diisopropylamino)phosphine (0.219 mL, 0.586 mmol) is added. After allowing to warm to room temperature the mixture is stirred for 1 hour. 30% hydrogen peroxide/water (30:70, 60 μL, 0.586 mmol) is added. After 1 hour sodium bisulfate (4 mL) is added and water (10 mL) is added. The reaction mixture is extracted with ethylacetate (2×15 mL). The combined organics are dried over MgSO4, filtered and evaporated to give the crude product, which is purified by silica chromatography eluting from 25% ethylacetate/heptanes to neat ethylacetate to give the title product (241 mg): m/z: 761.25.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09073894B2 |
|---|
| Source dataset | uspto-grants-2015_07 |
|---|
| ORD ID | ord-f81b824cc69646658d885e31e4021d94 |
|---|
| Source note | uspto-grants-2015_07 |
|---|
