関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | 4-Chloro-3-nitrobenzenesulfonamide | HCID 7324 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 1,4-Dioxane | HCID 31275 | — |
| 反応物 | 1-(2,2,2-Trifluoroethyl)piperidin-4-amine hydrochloride | HCID 17840002 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | HCID 67169936 | HCID 67169936 | — |
反応手順
4-chloro-3-nitrobenzenesulfonamide (1.300 g), 1-(2,2,2-trifluoroethyl)piperidin-4-amine hydrochloride (1.201 g), and triethylamine (2.30 mL) were added to 1,4-dioxane (50 mL) and water (5 mL) and heated at 90° C. for 16 hours. The solution was concentrated on vacuum and purified by flash column chromatography on silica gel with ethyl acetate increasing to 5% methanol in ethyl acetate.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09073855B2 |
|---|
| 出典データセット | uspto-grants-2015_07 |
|---|
| ORD ID | ord-d7b895ab6f3a4256bbe01fa96c7cefa0 |
|---|
| 出典メモ | uspto-grants-2015_07 |
|---|
