Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | (3-Bromopropoxy)(tert-butyl)dimethylsilane | HCID 607486 | — |
| Reactant | 3-Nitro-4-(piperidin-4-ylamino)benzenesulfonamide | HCID 43345806 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 67424970 | HCID 67424970 | — |
Reaction Steps
A mixture of EXAMPLE 157B (300 mg), (3-bromopropoxy)(tert-butyl)dimethylsilane (304 mg) and cesium carbonate (967 mg) was suspended in anhydrous N,N-dimethylformamide (5 mL). The reaction mixture was heated at 70° C. overnight. The reaction mixture was cooled to room temperature and diluted with ethyl acetate. The organic phase was washed with water, brine, dried over anhydrous sodium sulfate, and concentrated. The crude material was purified using flash column purification with 3-10% methanol/dichloromethane to afford the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09073855B2 |
|---|
| Source dataset | uspto-grants-2015_07 |
|---|
| ORD ID | ord-0ef02237987f46dfb57faf8a2237a929 |
|---|
| Source note | uspto-grants-2015_07 |
|---|
