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Diisopropylethylamine → 3-cyano-4-((tetrahydro-2H-pyran-4-yl)methylamino)benzenesulfonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | 4-Aminomethyltetrahydropyran | HCID 2773210 | — |
| 反応物 | 3-Cyano-4-fluorobenzene-1-sulfonamide | HCID 25139897 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 溶媒 | Ethyl Acetate | HCID 8857 | — |
| 生成物 | 3-cyano-4-((tetrahydro-2H-pyran-4-yl)methylamino)benzenesulfonamide | HCID 67126501 | — |
反応手順
3-Cyano-4-fluorobenzenesulfonamide (500 mg), (tetrahydropyran-4-yl)methylamine (288 mg), and N,N-diisopropylethylamine (1.3 mL) were heated at 80° C. in tetrahydrofuran (15 mL) overnight. The mixture was diluted with ethyl acetate, washed with NaHCO3 solution and brine, and dried (Na2SO4), filtered and concentrated. The product was triturated from ethyl acetate.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09073855B2 |
| 出典データセット | uspto-grants-2015_07 |
| ORD ID | ord-8ac759f32af9486196001fe9cfaa9139 |
| 出典メモ | uspto-grants-2015_07 |