HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1520655Generated: November 4, 2026
Diisopropylethylamine → HCID 86642506, compound
https://huagongshe.com/reaction/1520655
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | (3R)-(+)-3-(tert-Butoxycarbonylamino)pyrrolidine | HCID 1514397 | — |
| Reactant | 1,1-Difluoro-2-iodoethane | HCID 3833565 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 86642506 | HCID 86642506 | — |
Reaction Steps
To a solution of (R)-tert-butyl pyrrolidin-3-ylcarbamate (500 mg), 1,1-difluoro-2-iodoethane (618 mg) in N,N-dimethylformamide (6 mL) was added N-ethyl-N-isopropylpropan-2-amine (1.403 mL) and the reaction stirred for 72 hours at 70° C. The reaction mixture was concentrated and the crude product was purified on a silica gel and was eluted with a 0, 2, and 5% methanol in methylene chloride step gradient to provide the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09073855B2 |
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| Source dataset | uspto-grants-2015_07 |
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| ORD ID | ord-424271fbed4c451fa439719036f32a1d |
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| Source note | uspto-grants-2015_07 |
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