5-(2-chlorophenyl)-1H-pyrazole-3-carboxylic acid → HCID 71087796, compound

HRID 1520767Notes

Reaction equation

HRID 1520767 reaction equation
Cl.[Cl:2]C1C=CC([C:9]2[CH:13]=[C:12]([C:14]([NH:16][C:17]3[CH:22]=[CH:21][C:20]([C@H:23]4[O:28][CH2:27][CH2:26][NH:25][CH2:24]4)=[CH:19][CH:18]=3)=[O:15])[NH:11][N:10]=2)=CC=1.[Cl:29][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][C:31]=1C1C=C(C(O)=O)NN=1>>[ClH:2].[Cl:29][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][C:31]=1[C:9]1[CH:13]=[C:12]([C:14]([NH:16][C:17]2[CH:18]=[CH:19][C:20]([C@H:23]3[O:28][CH2:27][CH2:26][NH:25][CH2:24]3)=[CH:21][CH:22]=2)=[O:15])[NH:11][N:10]=1

Participants

3

Reactant 2

HCID 6463035-(2-chlorophenyl)-1H-pyrazole-3-carboxylic acidHCID 71087594HCID 71087594, compound

Product 1

HCID 71087796HCID 71087796, compound

Procedure

The title compound was prepared in analogy to Example 1 using (R)-tert-butyl 2-(4-aminophenyl)morpholine-4-carboxylate (prepared in Example 12) instead of (S)-tert-butyl 2-(4-aminophenyl)morpholine-4-carboxylate and 3-(2-chlorophenyl)-1H-pyrazole-5-carboxylic acid (CAS-890621-13-3) instead of 3-phenyl-1H-pyrazole-5-carboxylic acid. Light brown solid. MS (ISP): 383.1 ([M+H]+).

Sources & evidence

ORD record
ord-a6f0c8e7b390431daf33124a3e63f651
Source dataset
uspto-grants-2015_07
Patent number
US09073911B2

Reaction notes

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