5-(3-Methoxyphenyl)-1H-pyrazole-3-carboxylic acid → HCID 71087753, compound

HRID 1520769Notes

Reaction equation

HRID 1520769 reaction equation
Cl.[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:13]=[C:12]([C:14]([NH:16][C:17]3[CH:22]=[CH:21][C:20]([C@H:23]4[O:28][CH2:27][CH2:26][NH:25][CH2:24]4)=[CH:19][CH:18]=3)=[O:15])[NH:11][N:10]=2)=[CH:5][CH:4]=1.[CH3:29][O:30]C1C=C(C2C=C(C(O)=O)NN=2)C=CC=1>>[ClH:2].[CH3:29][O:30][C:4]1[CH:5]=[C:6]([C:9]2[CH:13]=[C:12]([C:14]([NH:16][C:17]3[CH:22]=[CH:21][C:20]([C@H:23]4[O:28][CH2:27][CH2:26][NH:25][CH2:24]4)=[CH:19][CH:18]=3)=[O:15])[NH:11][N:10]=2)[CH:7]=[CH:8][CH:3]=1

Participants

3

Reactant 2

HCID 13990245-(3-Methoxyphenyl)-1H-pyrazole-3-carboxylic acidHCID 71087594HCID 71087594, compound

Product 1

HCID 71087753HCID 71087753, compound

Procedure

The title compound was prepared in analogy to Example 1 using (R)-tert-butyl 2-(4-aminophenyl)morpholine-4-carboxylate (prepared in Example 12) instead of (S)-tert-butyl 2-(4-aminophenyl)morpholine-4-carboxylate and 3-(3-methoxyphenyl)-1H-pyrazole-5-carboxylic acid (CAS-890591-64-7) instead of 3-phenyl-1H-pyrazole-5-carboxylic acid. White solid. MS (ISP): 379.2 ([M+H]+).

Sources & evidence

ORD record
ord-b259932d35cc400ea9c2a7a4019bc0d4
Source dataset
uspto-grants-2015_07
Patent number
US09073911B2

Reaction notes

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