1-methyl-3-phenyl-1H-pyrazole-5-carboxylic acid → HCID 71087833, compound

HRID 1520770Notes

Reaction equation

HRID 1520770 reaction equation
Cl.[Cl:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:13]=[C:12]([C:14]([NH:16][C:17]3[CH:22]=[CH:21][C:20]([C@H:23]4[O:28][CH2:27][CH2:26][NH:25][CH2:24]4)=[CH:19][CH:18]=3)=[O:15])[NH:11][N:10]=2)=[CH:5][CH:4]=1.[CH3:29]N1C(C(O)=O)=CC(C2C=CC=CC=2)=N1>>[ClH:2].[CH3:29][N:11]1[C:12]([C:14]([NH:16][C:17]2[CH:22]=[CH:21][C:20]([C@H:23]3[O:28][CH2:27][CH2:26][NH:25][CH2:24]3)=[CH:19][CH:18]=2)=[O:15])=[CH:13][C:9]([C:6]2[CH:7]=[CH:8][CH:3]=[CH:4][CH:5]=2)=[N:10]1

Participants

3

Reactant 2

HCID 75376251-methyl-3-phenyl-1H-pyrazole-5-carboxylic acidHCID 71087594HCID 71087594, compound

Product 1

HCID 71087833HCID 71087833, compound

Procedure

The title compound was prepared in analogy to Example 1 using (R)-tert-butyl 2-(4-aminophenyl)morpholine-4-carboxylate (prepared in Example 12) instead of (S)-tert-butyl 2-(4-aminophenyl)morpholine-4-carboxylate and 1-Methyl-3-phenyl-1H-pyrazole-5-carboxylic acid (CAS-10250-64-3) instead of 3-phenyl-1H-pyrazole-5-carboxylic acid. White solid. MS (ISP): 363.3 ([M+H]+).

Sources & evidence

ORD record
ord-71c9f9baec7c4901869b0c18ffb2dc91
Source dataset
uspto-grants-2015_07
Patent number
US09073911B2

Reaction notes

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