Tert-butyl 3-(methylamino)propanoate → (+/-)-tert-butyl 3-(N-methyl-4-(1-(6-(4-phenyl-1H-pyrazol-1-yl)pyridin-3-ylamino)butyl)benzamido)propanoate

HRID 1520946Notes

Reaction equation

HRID 1520946 reaction equation
[C:1]1([C:7]2[CH:8]=[N:9][N:10]([C:12]3[N:17]=[CH:16][C:15]([NH:18][CH:19]([C:23]4[CH:33]=[CH:32][C:26]([C:27](OCC)=[O:28])=[CH:25][CH:24]=4)[CH2:20][CH2:21][CH3:22])=[CH:14][CH:13]=3)[CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:34][NH:35][CH2:36][CH2:37][C:38]([O:40][C:41]([CH3:44])([CH3:43])[CH3:42])=[O:39]>>[CH3:34][N:35]([CH2:36][CH2:37][C:38]([O:40][C:41]([CH3:44])([CH3:43])[CH3:42])=[O:39])[C:27](=[O:28])[C:26]1[CH:32]=[CH:33][C:23]([CH:19]([NH:18][C:15]2[CH:16]=[N:17][C:12]([N:10]3[CH:11]=[C:7]([C:1]4[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=4)[CH:8]=[N:9]3)=[CH:13][CH:14]=2)[CH2:20][CH2:21][CH3:22])=[CH:24][CH:25]=1

Participants

3

Reactant 2

HCID 14760311Tert-butyl 3-(methylamino)propanoateHCID 68157145ethyl 4-(1-(6-(4-phenyl-1H-pyrazol-1-yl)pyridin-3-ylamino)butyl)benzoate

Product 1

HCID 68178655(+/-)-tert-butyl 3-(N-methyl-4-(1-(6-(4-phenyl-1H-pyrazol-1-yl)pyridin-3-ylamino)butyl)benzamido)propanoate

Procedure

The title compound was prepared by a method analogous to that described in Steps B and C of Example 2, using ethyl 4-(1-(6-(4-phenyl-1H-pyrazol-1-yl)pyridin-3-ylamino)butyl)benzoate and tert-butyl 3-(methylamino)propanoate. MS (M+1) 554.5.

Sources & evidence

ORD record
ord-ac57c865ef664391be0b7600bca1b579
Source dataset
uspto-grants-2015_07
Patent number
US09073871B2

Reaction notes

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