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Methyl 6-chloro-4-(trifluoromethyl)nicotinate → 6-(5-Methyl-3-phenyl-isoxazol-4-ylmethoxy)-4-trifluoromethyl-nicotinic acid methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl 6-chloro-4-(trifluoromethyl)nicotinate | HCID 2775340 | — |
| 反応物 | (5-Methyl-3-phenyl-1,2-oxazol-4-yl)methanol | HCID 2776149 | — |
| 生成物 | 6-(5-Methyl-3-phenyl-isoxazol-4-ylmethoxy)-4-trifluoromethyl-nicotinic acid methyl ester | HCID 68444933 | — |
反応手順
As described for example 5, (5-methyl-3-phenyl-isoxazol-4-yl)-methanol (3.47 g, 18.4 mmol) was converted using methyl 6-chloro-4-(trifluoromethyl)nicotinate instead of 6-chloronicotinonitrile to the title compound which was used directly in the next transformation without further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US09073908B2 |
| 出典データセット | uspto-grants-2015_07 |
| ORD ID | ord-8ae0227080424612af1544f735ed2468 |
| 出典メモ | uspto-grants-2015_07 |