Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
5-Hydroxy-3-phenyl-5-(trifluoromethyl)-4,5-dihydroisoxazole → 3-(4-Fluorophenyl)-5-(trifluoromethyl)-1,2-oxazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 5-Hydroxy-3-phenyl-5-(trifluoromethyl)-4,5-dihydroisoxazole | HCID 2880976 | — |
| 반응물 | 3-(4-Fluoro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-5-ol | HCID 2881538 | — |
| 생성물 | 3-(4-Fluorophenyl)-5-(trifluoromethyl)-1,2-oxazole | HCID 799214 | 98% |
반응 단계
As described for example 128b, rac-3-(4-fluoro-phenyl)-5-trifluoromethyl-4,5-dihydro-isoxazol-5-ol (35.6 g, 142.9 mmol), instead of 3-phenyl-5-hydroxy-5-(trifluoromethyl)isoxazoline, was converted to the title compound (32.2 g, 98%) which was obtained as a light brown solid. MS: m/e=298.1 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09073908B2 |
| 출처 데이터셋 | uspto-grants-2015_07 |
| ORD ID | ord-c306d61253b94cd991a9eccba5a114fc |
| 출처 메모 | uspto-grants-2015_07 |