6-[3-(3-Fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-nicotinic acid methyl ester → HCID 68444797, compound

HRID 1521141Notes

Reaction equation

HRID 1521141 reaction equation
CO[C:3](=[O:24])[C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:11][C:12]2[C:13]([C:18]3[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=3)=[N:14][O:15][C:16]=2[CH3:17])=[N:6][CH:5]=1.COC(=O)C1C=CC(OCC2[C:37]([C:42]3[CH:47]=[CH:46]C=C(F)C=3)=[N:38]OC=2C)=NC=1>>[CH:42]1([CH2:37][NH:38][C:3](=[O:24])[C:4]2[CH:9]=[CH:8][C:7]([O:10][CH2:11][C:12]3[C:13]([C:18]4[CH:19]=[N:20][CH:21]=[CH:22][CH:23]=4)=[N:14][O:15][C:16]=3[CH3:17])=[N:6][CH:5]=2)[CH2:47][CH2:46]1

Participants

3

Reactant 2

HCID 684418946-[3-(3-Fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-nicotinic acid methyl esterHCID 68442066HCID 68442066, compound

Product 1

HCID 68444797HCID 68444797, compoundYield 67%

Procedure

As described for example 90, 6-(5-methyl-3-pyridin-3-yl-isoxazol-4-ylmethoxy)-nicotinic acid methyl ester (130 mg, 0.4 mmol), instead of 6-[3-(3-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-nicotinic acid methyl ester, was converted to the title compound (98 mg, 67%) which was obtained as a light yellow solid. MS: m/e=365.1 [M+H]+.

Sources & evidence

ORD record
ord-4256663777db4ac9ab85d3befb84990e
Source dataset
uspto-grants-2015_07
Patent number
US09073908B2

Reaction notes

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