HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Methyl-3-m-tolyl-isoxazole-4-carboxylic acid ethyl ester → (5-Methyl-3-(m-tolyl)isoxazol-4-yl)methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Methyl-3-m-tolyl-isoxazole-4-carboxylic acid ethyl ester | HCID 22309055 | — |
| Reactant | Ethyl 3-(2-fluorophenyl)-5-methylisoxazole-4-carboxylate | HCID 68442729 | — |
| Product | (5-Methyl-3-(m-tolyl)isoxazol-4-yl)methanol | HCID 68444867 | 77% |
Reaction Steps
As described for example 84d, 5-methyl-3-m-tolyl-isoxazole-4-carboxylic acid ethyl ester (5.1 g, 20.8 mmol) was converted, instead of 3-(2-fluoro-phenyl)-5-methyl-isoxazole-4-carboxylic acid ethyl ester, to the title compound (3.2 g, 77%) which was obtained as a light yellow oil. MS: m/e=262.3 [M+OAc]−.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09073908B2 |
| Source dataset | uspto-grants-2015_07 |
| ORD ID | ord-6d9bec9cbd234492b086e9ab5cdc1d8e |
| Source note | uspto-grants-2015_07 |