Ethyl 3-(2,4-difluorophenyl)-5-methylisoxazole-4-carboxylate → [3-(2,4-Difluoro-phenyl)-5-methyl-isoxazol-4-yl]-methanol

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Reaction Steps

As described for example 84d, 3-(2,4-difluoro-phenyl)-5-methyl-isoxazole-4-carboxylic acid ethyl ester (61.9 g, 232 mmol) was converted, instead of 3-(2-fluoro-phenyl)-5-methyl-isoxazole-4-carboxylic acid ethyl ester, to the title compound (20.3 g, 39%) which was obtained as a light brown solid. MS: m/e=284.1 [M+OAc]−.

Provenance & Evidence