HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(4-Chloro-2-fluoro-phenyl)-5-methyl-isoxazole-4-carboxylic acid ethyl ester → [3-(4-Chloro-2-fluoro-phenyl)-5-methyl-isoxazol-4-yl]-methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(4-Chloro-2-fluoro-phenyl)-5-methyl-isoxazole-4-carboxylic acid ethyl ester | HCID 68442634 | — |
| Reactant | Ethyl 3-(2-fluorophenyl)-5-methylisoxazole-4-carboxylate | HCID 68442729 | — |
| Product | [3-(4-Chloro-2-fluoro-phenyl)-5-methyl-isoxazol-4-yl]-methanol | HCID 68445569 | 43.5% |
Reaction Steps
As described for example 84d, 3-(4-chloro-2-fluoro-phenyl)-5-methyl-isoxazole-4-carboxylic acid ethyl ester (6.3 g, 20 mmol) was converted, instead of 3-(2-fluoro-phenyl)-5-methyl-isoxazole-4-carboxylic acid ethyl ester, to the title compound (2.1 g, 43%) which was obtained as an orange solid. MS: m/e=242.2 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09073908B2 |
| Source dataset | uspto-grants-2015_07 |
| ORD ID | ord-85ba03eb69d14ecf987d5ac5a07d8e07 |
| Source note | uspto-grants-2015_07 |