HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
3-Amino-1-propanol → 6-[3-(4-Chloro-phenyl)-isoxazol-4-ylmethoxy]-N-(3-hydroxy-propyl)-nicotinamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 3-Amino-1-propanol | HCID 9086 | — |
| Edukt | 6-[3-(4-Chloro-phenyl)-isoxazol-4-ylmethoxy]-nicotinic acid | HCID 68443769 | — |
| Produkt | 6-[3-(4-Chloro-phenyl)-isoxazol-4-ylmethoxy]-N-(3-hydroxy-propyl)-nicotinamide | HCID 68444628 | 60% |
Reaktionsschritte
As described for example 346b, 6-[3-(4-chloro-phenyl)-isoxazol-4-ylmethoxy]-nicotinic acid (200 mg, 0.6 mmol) was converted, using 3-amino-1-propanol instead of ethanolamine, to the title compound (140 mg, 60%) which was obtained as a white solid. MS: m/e=385.9 [M−H]−.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US09073908B2 |
| Quelldatensatz | uspto-grants-2015_07 |
| ORD ID | ord-63ad130f75cf4bedb6b1609651699737 |
| Quellennotiz | uspto-grants-2015_07 |