HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-(2-aminoethyl)acetamide → N-(2-Acetylamino-ethyl)-6-[3-(4-chloro-phenyl)-isoxazol-4-ylmethoxy]-nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-(2-aminoethyl)acetamide | HCID 66082 | — |
| Reactant | 6-[3-(4-Chloro-phenyl)-isoxazol-4-ylmethoxy]-nicotinic acid | HCID 68443769 | — |
| Product | N-(2-Acetylamino-ethyl)-6-[3-(4-chloro-phenyl)-isoxazol-4-ylmethoxy]-nicotinamide | HCID 68442478 | 48% |
Reaction Steps
As described for example 346b, 6-[3-(4-chloro-phenyl)-isoxazol-4-ylmethoxy]-nicotinic acid (200 mg, 0.6 mmol) was converted, using N-acetylethylenediamine instead of ethanolamine, to the title compound (120 mg, 48%) which was obtained as a white solid. MS: m/e=413.1 [M−H]−.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09073908B2 |
| Source dataset | uspto-grants-2015_07 |
| ORD ID | ord-9641c8c16da543129bc6110bf63ea2f7 |
| Source note | uspto-grants-2015_07 |