Ammonia → 5-Bromo-4-fluoro-2-nitroaniline

HRID 1521408Notes

Reaction equation

HRID 1521408 reaction equation
[Br:1][C:2]1[CH:7]=[C:6](F)[C:5]([N+:9]([O-:11])=[O:10])=[CH:4][C:3]=1[F:12].[NH3:13]>CO>[Br:1][C:2]1[C:3]([F:12])=[CH:4][C:5]([N+:9]([O-:11])=[O:10])=[C:6]([NH2:13])[CH:7]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 27362864-Bromo-2,5-difluoronitrobenzene

Product 1

HCID 669372515-Bromo-4-fluoro-2-nitroaniline

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
60 °C

Procedure

A mixture of 1-bromo-2,5-difluoro-4-nitro-benzene (1.50 g, 6.30 mmol) and 7M ammonia in methanol (25 mL) was heated in a sealed tube at 60° C. for 15 h. The reaction mixture was transferred to a round bottom flask, washing the sealed tube with EtOAc. The reaction mixture was concentrated, and the crude material was used in the next step without further purification.

Workup

  1. customThe reaction mixture was transferred to a round bottom flask
  2. washwashing the sealed tube with EtOAc
  3. concentrationThe reaction mixture was concentrated
  4. customthe crude material was used in the next step without further purification

Sources & evidence

ORD record
ord-cdf2365b278d43e28c510b98e9a959f3
Source dataset
uspto-grants-2015_07
Patent number
US09073923B2

Reaction notes

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