反应详情

To a solution of the title compound from Example 73 Step A (114 mg, 0.500 mmol) in acetonitrile (2.5 mL) was added Dess-Martin Periodinane (254 mg, 0.600 mmol). The reaction stirred at room temperature until complete. It was then concentrated under reduced pressure, diluted with 2% methanol in dichloromethane, and passed through a syringe filter. Purification by flash chromatography on silica gel (20-100% ethyl acetate in hexanes) provided the title compound: LCMS m/z 227.86 [M+2+H]+.

1. concentrationIt was then concentrated under reduced pressure
2. additiondiluted with 2% methanol in dichloromethane
3. custompassed through a syringe
4. filtrationfilter
5. customPurification by flash chromatography on silica gel (20-100% ethyl acetate in hexanes)