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0 °C

To a stirred solution of 2-fluoroaniline (15 g, 0.135 mol) in dichloromethane (100 mL) was added 3-chloropropanoyl chloride (15.168 mL, 0.135 mol) under cooling condition (0° C.) with constant stirring. Reaction mass was allowed to stir at room temperature for 2 h. The reaction mixture was diluted with water (200 mL) and extracted with dichloromethane (4×100 mL). The combined organic layer was washed with saturated aqueous sodium chloride solution, dried over sodium sulphate and concentrated under vacuum to obtain the title compound. MS (M+1): 201.9.

1. customReaction mass
2. extractionextracted with dichloromethane (4×100 mL)
3. washThe combined organic layer was washed with saturated aqueous sodium chloride solution
4. dry with materialdried over sodium sulphate
5. concentrationconcentrated under vacuum