反应详情

温度

120 °C

To a stirred solution of 6-bromo-8-fluoro-3,4-dihydroquinoline-2(1H)-thione (109-4; 3.0 g, 0.011 mol) in n-butanol (25 mL) was added acetic hydrazide (4.81 g, 0.065 mol) and then followed by the addition of molecular sieves. Reaction mass was heated to 120° C. for 16 h. The reaction mixture was concentrated and directly purified by silica gel column chromatography to obtain title compound. MS (M+1): 284.2.

1. additionfollowed by the addition of molecular sieves
2. customReaction mass
3. concentrationThe reaction mixture was concentrated
4. customdirectly purified by silica gel column chromatography