HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1521647Generated: October 31, 2026
Lawesson's reagent → 6-bromo-5-chloro-3,4-dihydroquinoline-2(1H)-thione
https://huagongshe.com/reaction/1521647
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Lawesson's reagent | HCID 87949 | — |
| Reactant | 6-Bromo-5-chloro-1,2,3,4-tetrahydroquinolin-2-one | HCID 70979211 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | 6-bromo-5-chloro-3,4-dihydroquinoline-2(1H)-thione | HCID 89961706 | — |
Reaction Steps
To a stirred solution of 6-bromo-5-chloro-3,4-dihydroquinolin-2(1H)-one (143-5; 1.2 g, 0.0046 mol) in toluene (20 mL) was added Lawesson's reagent (1.8 g, 0.0046 mol). Reaction mass was refluxed at 100° C. for 12 h. The reaction mixture was concentrated and directly purified by silica gel column chromatography to obtain title compound 6-bromo-5-chloro-3,4-dihydroquinoline-2(1H)-thione. MS (M+1): 277.8.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09073929B2 |
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| Source dataset | uspto-grants-2015_07 |
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| ORD ID | ord-4a10e994832a43059918077d6957d353 |
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| Source note | uspto-grants-2015_07 |
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