HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Bromosuccinamide → 6-Bromo-5-fluoro-1,2,3,4-tetrahydroquinolin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Bromosuccinamide | HCID 9834204 | — |
| Reactant | 5-Fluoro-3,4-dihydroquinolin-2(1H)-one | HCID 22736942 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 6-Bromo-5-fluoro-1,2,3,4-tetrahydroquinolin-2-one | HCID 70980148 | — |
Reaction Steps
To a stirred solution of 5-fluoro-3,4-dihydroquinolin-2(1H)-one (146-4; 0.45 g, 0.00272 mol) in N,N-dimethylformamide (10 mL) was added N-bromosuccinamide (0.53 g, 0.0029 mol). Reaction mass was allowed to stir for overnight. Ice cold water was added to reaction mass. The solid separated was filtered and dried thoroughly to obtain the title compound. MS (M+1): 246.0.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09073929B2 |
| Source dataset | uspto-grants-2015_07 |
| ORD ID | ord-80f57e261f5a44dcac8d28ddc0847a22 |
| Source note | uspto-grants-2015_07 |