Phosphorus oxychloride → HCID 90408501, compound

Participants

Reaction Conditions

Reaction Steps

2-(4-Bromobenzyl)-5-methyl-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione (159 g, 475 mmol) is suspended in POCl3 (300 mL), and then slowly heated to reflux. After the mixture is refluxed for 60 h, POCl3 is removed under reduced pressure. The obtained residue is dissolved in methylene chloride (5 L), cooled to 0° C., and then adjusted to pH 8-9 with saturated sodium bicarbonate. After filtration, the obtained solids are washed with water twice, and then dried under vacuum to give 157 g of product (yield: 94%). MS (ESI) m/z 353.0 [M+H]+.

Provenance & Evidence