Potassium Carbonate → HCID 67236483, compound

Participants

Reaction Conditions

Reaction Steps

A stirred solution of benzyl 3-fluoro-4-nitrobenzoate (2.67 g, 9.69 mmol) and 3-amino-3-methylbutan-1-ol (1.00 g, 9.69 mmol) in acetonitrile (20 mL) containing potassium carbonate (1.34 g, 9.69 mmol) is heated to 80° C. for 16 h. The solvent is evaporated, water (100 mL) is added, and the mixture is extracted with EtOAc (3×100 mL). The combined organic layers are dried (MgSO4), concentrated and purified by flash chromatography in heptanes/EtOAc to afford the title compound (395 mg, 1.10 mmol).

Provenance & Evidence