Triphenylphosphine → HCID 67235192, compound

Participants

Reaction Steps

To a stirred solution of benzyl 3-[(4-hydroxy-2-methylbutan-2-yl)amino]-4-nitrobenzoate (395 mg, 1.10 mmol), di-tert-butyl iminodicarboxylate (367 mg, 1.65 mmol), and triphenylphosphine (430 mg, 1.65 mmol) in THF (5 mL) is added diisopropyl azodicarboxylate (0.34 mL, 1.65 mmol). After 16 h at room temperature the solvent is evaporated and the residue is purified by flash chromatography on silica eluting with a heptane/EtOAc gradient to afford the title compound (280 mg, 0.50 mmol, 46%).

Provenance & Evidence