HCID 67236651, compound → HCID 67245777, compound

HRID 1521695Notes

Reaction equation

HRID 1521695 reaction equation
[CH3:1][C:2]1([CH3:27])[N:11]2[C:7](=[N:8][C:9]3[CH:15]=[CH:14][C:13]([C:16]([O:18]CC4C=CC=CC=4)=[O:17])=[CH:12][C:10]=32)[C:6](=[O:26])[NH:5][CH2:4][CH2:3]1>CO.[Pd]>[CH3:1][C:2]1([CH3:27])[N:11]2[C:7](=[N:8][C:9]3[CH:15]=[CH:14][C:13]([C:16]([OH:18])=[O:17])=[CH:12][C:10]=32)[C:6](=[O:26])[NH:5][CH2:4][CH2:3]1

Participants

4

Reactant 1

HCID 67236651HCID 67236651, compound

Product 1

HCID 67245777HCID 67245777, compoundYield 63.2%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A suspension of benzyl 5,5-dimethyl-1-oxo-2,3,4,5-tetrahydro-1H-[1,4]diazepino[1,2-a]benzimidazole-8-carboxylate (88 mg, 0.22 mmol) in methanol (2 mL) is hydrogenated over 10% palladium on carbon (23 mg) under balloon pressure for 3 h. The catalyst is removed by filtration, and the filtrate concentrated to afford the title compound (38 mg, 63%).

Workup

  1. customThe catalyst is removed by filtration
  2. concentrationthe filtrate concentrated

Sources & evidence

ORD record
ord-8313919a953544e89c507463297352c0
Source dataset
uspto-grants-2015_07
Patent number
US09073926B2

Reaction notes

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