참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Pyruvic Acid | HCID 1060 | — |
| 반응물 | Dabco | HCID 9237 | — |
| 반응물 | 2-Amino-6-chloro-3-iodopyridine | HCID 45480365 | — |
| 촉매 | palladium(II) acetate | HCID 167845 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 6-Chloro-1H-pyrrolo(2,3-b)pyridine-2-carboxylic acid | HCID 21976580 | 194.8% |
반응 단계
To a solution of 6-chloro-3-iodopyridin-2-amine (24 g, 94 mmol) in DMF is added DABCO (32 g, 283 mmol) and pyruvic acid (20 mL, 283 mmol). The mixture is degassed by bubbling argon gas through the mixture for 20 min. Pd(OAc)2 (1 g, 4.7 mmol) is added and the mixture is again degassed. The reaction mixture is heated at 110° C. for 3 h, and the solvent is evaporated to afford the title compound as a viscous liquid (36 g, >99%) which is used in the next step without purification.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09073926B2 |
|---|
| 출처 데이터셋 | uspto-grants-2015_07 |
|---|
| ORD ID | ord-99ed89870ee64cec90aa651c6f43d132 |
|---|
| 출처 메모 | uspto-grants-2015_07 |
|---|
