反应详情

To a solution of diethyl 1-{3-[(tert-butoxycarbonyl)amino]-2,2-dimethylpropyl}-1H-pyrrolo[2,3-b]pyridine-2,6-dicarboxylate (4.20 g, 9.39 mmol) in CH2Cl2 (20 mL) is added TFA (10 mL). The mixture is stirred at room temperature for 4 hr. The solvent is evaporated and the residue is partitioned between ethyl acetate and saturated NaHCO3 solution. The layers are separated and the aqueous layer is further extracted with ethyl acetate. The combined organic phases are washed with brine, and are dried (Na2SO4) and concentrated in vacuo to afford the title compound (3.30 g, quantitative). LCMS: 348.79 (M+H+).

1. customThe solvent is evaporated
2. customthe residue is partitioned between ethyl acetate and saturated NaHCO3 solution
3. customThe layers are separated
4. extractionthe aqueous layer is further extracted with ethyl acetate
5. washThe combined organic phases are washed with brine
6. dry with materialare dried (Na2SO4)
7. concentrationconcentrated in vacuo