Sodium Hydroxide → HCID 89585820, compound

Participants

Reaction Conditions

Reaction Steps

To a suspension of ethyl trans-8,9-dimethyl-6-oxo-6,7,8,9-tetrahydropyrido[3′,2′:4,5]pyrrolo[1,2-a]pyrazine-2-carboxylate (702 mg, 2.44 mmol) in ethanol (20 mL) is added 1M aqueous NaOH solution (6.11 mL, 6.11 mmol). The reaction mixture is heated at 50° C. for 90 min and is cooled to room temperature. The ethanol is removed in vacuo and the aqueous mixture is acidified with 1N aqueous HCl. The resulting solid is collected by filtration and dried in vacuo to afford the title compound as a white solid (580 mg, 92%). LCMS: 260.64 (M+H+).

Provenance & Evidence