3-Furancarboxaldehyde, tetrahydro- → 1-(Tetrahydro-furan-3-ylmethyl)-1H-pyrazolo[3,4-b]pyridin-5-ylamine

HRID 1521736Notes

Reaction equation

HRID 1521736 reaction equation
[O:1]1[CH2:6][CH2:5][CH:4]([N:7]2[C:11]3=[N:12][CH:13]=[C:14]([NH2:16])[CH:15]=[C:10]3[CH:9]=[N:8]2)[CH2:3][CH2:2]1.O1CCC(C=O)C1>>[O:1]1[CH2:2][CH2:3][CH:5]([CH2:4][N:7]2[C:11]3=[N:12][CH:13]=[C:14]([NH2:16])[CH:15]=[C:10]3[CH:9]=[N:8]2)[CH2:6]1

Participants

3

Reactant 2

HCID 1575683-Furancarboxaldehyde, tetrahydro-HCID 672370741-(Tetrahydro-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-5-ylamine2×

Product 1

HCID 672367421-(Tetrahydro-furan-3-ylmethyl)-1H-pyrazolo[3,4-b]pyridin-5-ylamine

Procedure

1-(Tetrahydro-furan-3-ylmethyl)-1H-pyrazolo[3,4-b]pyridin-5-ylamine is synthesized using a similar procedure used to prepare (1-(Tetrahydro-pyran-4-yl)-1H-pyrazolo[3,4-b]pyridin-5-ylamine (Intermediate P), replacing tetrahydropyran-4-one with tetrahydro-furan-3-carbaldehyde in Step 1.

Sources & evidence

ORD record
ord-521bdceecbf740fe8277eff4eaffb4e0
Source dataset
uspto-grants-2015_07
Patent number
US09073926B2

Reaction notes

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