HCID 783358, compound → HCID 67234975, compound

Participants

Reaction Steps

To a solution of 4-(5-chloro-2-nitrobenzyl)morpholine (5.1 g, 19.9 mmol) in HOAc (75 mL) is carefully added zinc dust (3.9 g, 59.6 mmol). After 2 hours, the reaction is filtered through a bed of Celite and the filtrate is concentrated to remove most of the HOAc. The residue is then taken up in 2M aqueous K2CO3 and extracted with ethyl acetate. The organic layer is dried (Na2SO4) and concentrated to afford a brown oil. The crude material is purified by flash column chromatography using a gradient of 0-5% methanol/CH2Cl2 to afford the title compound (4.0 g, 12.4 mmol, 70% purity).

Provenance & Evidence