Stannous Chloride → HCID 67235894, compound

Participants

Reaction Steps

To a solution of tin (II) chloride (1.1 g, 6 mmol) in concentrated HCl (1.5 mL) is added 4-chloro-2-(morpholin-4-ylmethyl)-6-nitroaniline (543 mg, 2 mmol) as a solution in concentrated HCl (1 mL). The reaction is stirred for 1 hour. The thick slurry is filtered and the filter cake rinsed with HCl. The filter cake is dissolved in H2O (10 mL) and treated with 2M aqueous K2CO3 and extracted with CH2Cl2. The organic layer is separated, dried (Na2SO4) and concentrated to afford the title compound (458 mg, 95%) as an oil.

Provenance & Evidence