Hydrogen Bromide → HCID 178419265, compound

Participants

Reaction Steps

To a solution of 5-chloro-3-(morpholin-4-ylmethyl)benzene-1,2-diamine (458 mg, 1.9 mmol) in ethanol (5 mL) is added a 48% aqueous HBr solution (0.21 mL, 1.9 mmol) followed by a 3M solution of cyanogen bromide (0.95 mL, 2.8 mmol) in CH2Cl2. The reaction is stirred at room temperature for 4 h and is diluted with diethyl ether. The resulting solid is isolated by filtration to afford the title compound as the dihydrobromide salt (595 mg, 73%).

Provenance & Evidence