Ammonia → HCID 86682396, compound

Participants

Reaction Steps

To a solution of 6-chloro-N˜2˜-ethylpyridine-2,3-diamine (401 mg, 2.34 mmol) in ethanol (10 mL) is added a 3M solution of cyanogen bromide in CH2Cl2 (0.93 mL, 2.8 mmol) and the resulting solution is stirred for 6 h at room temperature. The solution is basified with ammonia in methanol and evaporated. The residue is purified via flash column chromatography using a gradient elution of 0-15% CH2Cl2/methanol containing 1% NH4OH to afford the title compound (212 mg, 46%).

Provenance & Evidence