Dimethylformamide → HCID 68322710, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 1-(3-tert-butoxycarbonylamino-propyl)-2-trimethoxymethyl-3H-benzimidazole-5-carboxylic acid (Intermediate A, 70 mg, 0.17 mmol) and PyBOP (95 mg, 0.18 mmol) in DMF (1 mL) was stirred for 10 min, and 3-aminopyridine (17 mg, 0.18 mmol) and triethylamine (46 μL, 0.33 mmol) are added. The solution is heated in a block heater at 45° C. for 20 h. The solution is diluted with EtOAc and is washed with Na2CO3, H2O, and brine. The organic layer is dried (MgSO4) and evaporated to afford the title compound (102 mg, 0.16 mmol, 99%) as an oil that was used in the next step without purification.

Provenance & Evidence