5-Aminoisoxazole → HCID 178428416, compound

Participants

Reaction Steps

A mixture of 50 mg (0.22 mmol) (2E)-2-[(3-methyl-1H-indazol-5-yl)methylidene]-3-oxobutane-nitrite (Example 2A) and 19 mg (0.22 mmol) 1,2-oxazol-5-amine in propan-2-ol (1.0 ml) was stirred at reflux temperature overnight. The reaction mixture was then concentrated under reduced pressure, and the residue was purified by preparative RP-HPLC (acetonitrile/water+0.1% TFA gradient) to yield 45 mg (69% of th.) of the racemic title compound.

Provenance & Evidence